Por V. R. Ferraz, J. L. Vitorino Araujo, L. Sementilli, J. F. Neto, e J. C. E. Veiga
Abstract
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and the fifth most common cancer in the world. The lungs, bone, and lymph nodes are frequent sites of metastasis of HCC. The purpose of the present study is show that metastases, although rare, must be among the differential diagnosis of skin lesions and that a diagnostic research based on these findings can be conducted. The authors report a rare case of metastatic hepatocellular injury to the scalp and skull treated by a radical surgical approach. Excision of the lesion in the scalp was performed “en bloc.” The tumor was supplied by the frontal branch of the superficial temporal artery. There are few case reports of metastatic HCC to scalp and skull; treatment of these lesions should be individualized in order to control symptoms, improve quality of life, and promote an increase in survival.
Introduction
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and the fifth most common cancer in the world. It remains the fastest-growing cause of cancer death in men. The lung, bone, and lymph nodes are frequent sites of metastasis of HCC. The most common sites for distant skin metastasis of internal carcinomas are the chest, back, and abdomen [1].
In this paper we report a rare case of metastatic hepatocellular injury to the scalp and skull that underwent radical surgical approach with favorable outcome after six months.
Materials and Methods
In this paper we report a single rare case of metastatic hepatocellular injury to the scalp and skull treated by a radical surgical approach with good metastatic control. The patient and his family were informed about this publication and agreed to the publication of medical information about the patient. Immunohistochemistry was performed using antibodies against Hepatocyte (Dako®), polyclonal CEA (pCEA) (Neomarkers®), CD10 (Neomarkers), Villin (Neomarkers), CD34 (Neomarkers), TTF-1 (Zymed®), MOC-31 (Neomarkers), CK7 (Neomarkers), and CK20 (Neomarkers). The following tests were positive: Villin, pCEA, CD34, CK7, CD10, and Hepatocyte.
Dako is a manufacturer in Glostrup, Denmark, and Carpinteria, California, United States. Neomarkers Inc. is a manufacturer in Fremont, California, United States. Zymed Laboratories Inc. is a manufacturer in San Francisco, California, United States.
